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Product Description
anti- AATF antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease(presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date..
Immunogen: apoptosis antagonizing transcription factor
Synonyms: AATF, CHE 1, CHE1, DED, Protein AATF, Rb binding protein Che 1, Traube
Reactivity: Human, Mouse, Rat
Tested Application: ELISA, WB, IF
Recommended dilution: WB: 1:200-1:2000; IF: 1:10-1:100
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Image 4: mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab00025(AATF antibody) at dilution of 1:800
Gene ID: 26574
Research Area: Metabolism
Uniprot ID: Q9NY61
