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Product Description
anti- ABCA4 antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2..
Immunogen: ABCA4
Synonyms: ABC10, ABCR, ARMD2, CORD3, FFM, RMP, RP19, STGD, STGD1
Reactivity: Human
Tested Application: ELISA, IHC
Recommended dilution: IHC: 1:20-1:200
Image 1: Immunohistochemistry of paraffin-embedded human colon cancer using FNab10057(ABCA4 antibody) at dilution of 1:100
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Gene ID: 24
Research Area: Metabolism
Uniprot ID: P78363
