anti- ACK1 antibody

Product Description

anti- ACK1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: TNK2, also named as ACK1, belongs to the protein kinase superfamily and Tyr protein kinase family. It is a non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. TNK2 transduces extracellular signals to cytosolic and nuclear effectors. It is a downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. TNK2 confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. The 60-70kd band is the isoform 2 of TNK2. Isoform 1 and 3 is about 120-125kd..

Immunogen: tyrosine kinase, non-receptor, 2

Synonyms: TNK2, ACK1, ACK, FLJ45547, ACK 1

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:200-1:2000; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human breast cancer using FNab00086(ACK1 antibody) at dilution of 1:50

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Image 4: SH-SY5Y cells were subjected to SDS PAGE followed by western blot with FNab00086(ACK1 antibody) at dilution of 1:500

Gene ID: 10188

Research Area: Metabolism

Uniprot ID: Q07912