anti- ADAM17-Specific antibody

Product Description

anti- ADAM17-Specific antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: The ADAMs(A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor(TNF)-a from its precursor(PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092). This antibody is specific to ADAM17..

Immunogen: ADAM metallopeptidase domain 17

Synonyms: ADAM 17, ADAM17, CD156b, cSVP, Snake venom like protease, TACE, TNF alpha convertase, TNF alpha converting enzyme

Reactivity: Human

Tested Application: ELISA, WB

Recommended dilution: WB: 1:200-1:2000; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using FNab00139(ADAM17-Specific Antibody) at dilution of 1:200

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Image 4: human placenta tissue were subjected to SDS PAGE followed by western blot with FNab00139(ADAM17-Specific antibody) at dilution of 1:500

Gene ID: 6868

Research Area: Metabolism

Uniprot ID: P78536