anti- AGER antibody

Product Description

anti- AGER antibody is available at Gentaur for Next week Delivery.

Purification: protein A+G purified

Background: Mediates interactions of advanced glycosylation end products(AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling(By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide(ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase(MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides..

Immunogen: advanced glycosylation end product-specific receptor

Synonyms: AGER, RAGE

Reactivity: Human, Rat

Tested Application: ELISA, WB

Recommended dilution: WB: 1:1000-1:5000

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Image 4: Rar lung tissue were subjected to SDS PAGE followed by western blot with FNab09951(AGER Antibody) at dilution of 1:2000

Gene ID: 177

Research Area: Metabolism

Uniprot ID: Q15109