anti- AIF antibody

Product Description

anti- AIF antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10..

Immunogen: apoptosis-inducing factor, mitochondrion-associated, 1

Synonyms: AIF, AIFM1, PDCD8

Reactivity: Human, Mouse

Tested Application: ELISA, IHC, WB, IF

Recommended dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Image 1: Immunohistochemistry of paraffin-embedded human esophagus tissue slide using FNab00235( AIF Antibody) at dilution of 1:100

Image 2: Immunofluorescence analysis of U2OS cells using FNab00235( AIF Antibody). Blue: DAPI for nuclear staining..

Image 3:

Image 4: Jurkat cells were subjected to SDS PAGE followed by western blot with FNab00235(AIF antibody) at dilution of 1:1000

Gene ID: 9131

Research Area: Metabolism

Uniprot ID: O95831