anti- AIM2 antibody

Product Description

anti- AIM2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8(By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity..

Immunogen: absent in melanoma 2

Synonyms: Absent in melanoma 2, AIM2, PYHIN4

Reactivity: Human

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:500-1:5000; IHC: 1:20-200

Image 1: Immunohistochemistry of paraffin-embedded human testis using FNab00238(AIM2 antibody) at dilution of 1:100

Image 2: .

Image 3:

Image 4: K-562 cells were subjected to SDS PAGE followed by western blot with FNab00238(AIM2 antibody) at dilution of 1:1000

Gene ID: 9447

Research Area: Metabolism

Uniprot ID: O14862