anti- AIRE antibody

Product Description

anti- AIRE antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes(By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions..

Immunogen: autoimmune regulator

Synonyms: AIRE, AIRE1, APECED, APECED protein, APS1, APSI, autoimmune regulator, PGA1

Reactivity: Human, Mouse

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:500-1:5000; IHC: 1:20-200

Image 1: Immunohistochemistry of paraffin-embedded human stomach slide using FNab00241(AIRE Antibody) at dilution of 1:50

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Image 4: L02 cells were subjected to SDS PAGE followed by western blot with FNab00241(AIRE Antibody) at dilution of 1:1000

Gene ID: 326

Research Area: Metabolism

Uniprot ID: O43918