anti- AKT3 antibody

Product Description

anti- AKT3 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: AKT3 is one of 3 closely related serine/threonine-protein kinases(AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis..

Immunogen: v-akt murine thymoma viral oncogene homolog 3(protein kinase B, gamma)

Synonyms: AKT3, DKFZp434N0250, PKB GAMMA, PKBG, PRKBG, Protein kinase Akt 3, Protein kinase B gamma, RAC gamma, RAC PK gamma, STK 2

Reactivity: Human, Mouse, Rat, Zebrafish

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:200-1:2000; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab00273(AKT3 Antibody) at dilution of 1:50

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Image 4: MCF7 cells were subjected to SDS PAGE followed by western blot with FNab00273(AKT3 antibody) at dilution of 1:500

Gene ID: 10000

Research Area: Metabolism

Uniprot ID: Q9Y243