anti- ALK,CD246 antibody

Product Description

anti- ALK,CD246 antibody is available at Gentaur for Next week Delivery.

Purification: Protein A+G purification

Background: ALK, also named as CD246, is a receptor tyrosine kinase(RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM(Nucleophosmin)-ALK oncogenic fusion protein, resulting from the(2;5)(p23;q35) translocation that is frequently associated with anaplastic large-cell lymphoma(ALCL). The EML4(echinoderm microtubule-associated protein-like 4)-ALK fusion protein have been described in non-small-cell lung cancer(NSCLC), this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC(PMID: 17625570)..

Immunogen: anaplastic lymphoma receptor tyrosine kinase

Synonyms: ALK, ALK tyrosine kinase receptor, ALK,CD246, Anaplastic lymphoma kinase, CD246, TFG/ALK

Reactivity: Human

Tested Application: ELISA, IHC, WB

Recommended dilution: WB: 1:500-1:2000; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human lymphoma slide using FNab00310(ALK,CD246 Antibody) at dilution of 1:50

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Image 4: Recombinant protein were subjected to SDS PAGE followed by western blot with FNab00310(ALK,CD246 Antibody) at dilution of 1:1000

Gene ID: 238

Research Area: Metabolism

Uniprot ID: Q9UM73