anti- Alpha-1-Antitrypsin antibody

Product Description

anti- Alpha-1-Antitrypsin antibody is available at Gentaur for Next week Delivery.

Purification: Protein A+G purification

Background: SERPINA1 is the gene for a protein called alpha-1-antitrypsin(AAT), which is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. AAT is a glycoprotein synthesized primarily by hepatocytes, with smaller amountssynthesized by intestinal epithelial cells, neutrophils, pulmonary alveolar cells and macrophages. AAT is the most abundant, endogenous serine protease inhibitor in blood circulation and it has been implicated in regulating vital fluid phase biological events such as blood coagulation, fibrinolysis, complement activation, apoptosis, reproduction, tumor progression and inflammatory response. The primary function of AAT is thought to be the inactivation of neutrophil elastase and other endogenous serine proteases. Defects in SERPINA1 can cause emphysema or liver disease..

Immunogen: serpin peptidase inhibitor, clade A(alpha-1 antiproteinase, antitrypsin), member 1

Synonyms: A1A, A1AT, AAT, Alpha 1 antiproteinase, Alpha 1 antitrypsin, Alpha 1 protease inhibitor, PI, PI1, PRO2209, PRO2275, Serpin A1, SERPINA1, SPAAT, ?1-antitrypsin

Reactivity: Human, Rat

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:500-1:5000; IP: 1:500-1:2000; IF: 1:20-1:200; IHC: 1:500-1:1000

Image 1: Immunohistochemistry of paraffin-embedded human liver using FNab00338(Alpha-1-Antitrypsin antibody) at dilution of 1:1000

Image 2: Immunofluorescent analysis of HepG2 cells using FNab00338( Alpha-1-Antitrypsin Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L).

Image 3:

Image 4: HepG2 cells were subjected to SDS PAGE followed by western blot with FNab00338(Alpha-1-Antitrypsin antibody) at dilution of 1:1000

Gene ID: 5265

Research Area: Metabolism

Uniprot ID: P01009