anti- AMACR/p504S antibody

Product Description

anti- AMACR/p504S antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer(PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR(PMID:12213712). It has 3 isoforms produced by alternative splicing ang it can form a a dimer of 70-75 kDa(PMID:21812041). Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency(AMACRD) and congenital bile acid synthesis defect type 4(CBAS4)..

Immunogen: alpha-methylacyl-CoA racemase

Synonyms: 2 methylacyl CoA racemase, alpha methylacyl CoA racemase, AMACR, CBAS4, p504S, RACE

Reactivity: Human

Tested Application: ELISA, IHC, WB

Recommended dilution: WB: 1:500-1:5000; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human prostate cancer using FNab00355(p50S,AMACR antibody) at dilution of 1:50

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Image 4: Recombinant AMACR protein were subjected to SDS PAGE followed by western blot with FNab00355(AMACR Antibody) at dilution of 1:1000

Gene ID:

Research Area: Metabolism

Uniprot ID: Q9UHK6