anti- Amphiregulin antibody

Product Description

anti- Amphiregulin antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Amphiregulin(AREG) is one of the ligands of the epidermal growth factor receptor(EGFR). AREG plays a central role in mammary gland development and branching morphogenesis in organs and is expressed both in physiological and in cancerous tissues. The AREG protein is synthesized as a 252-amino acid transmembrane precursor, pro-AREG. At the plasma membrane, pro-AREG is subjected to sequential proteolytic cleavages within its ectodomain and is then released as the soluble AREG protein. Depending on the cell type and microenvironment, AREG can be produced in multiple cellular and mature forms using alternative pro-AREG cleavage sites and glycosylation motifs. Post-translastional modfications of 50-kDa pro-AREG produces a major soluble 43-kDa form, 28-, 26-, 16-kDa membrane anchored forms, and soluble 21-, 19-, and 9-kDa forms(PMID: 9642297)..

Immunogen: amphiregulin

Synonyms: Amphiregulin, AR, AREG, AREGB, CRDGF, SDGF

Reactivity: Human

Tested Application: ELISA, IF, WB, IHC, FC, IP

Recommended dilution: WB: 1:200-1:2000; IHC: 1:50-1:500; IP: 1:1000-1:10000; IF: 1:10-1:100

Image 1: Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using FNab00374(AREG Antibody) at dilution of 1:200. heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

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Image 4: MCF-7 cells were subjected to SDS PAGE followed by western blot with FNab00374(AREG Antibody) at dilution of 1:600

Gene ID: 374

Research Area: Metabolism

Uniprot ID: P15514