anti- APC antibody

Product Description

anti- APC antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor(HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization..

Immunogen: adenomatous polyposis coli

Synonyms: adenomatous polyposis coli, APC, BTPS2, Deleted in polyposis 2.5, DP2, DP2.5, DP3, GS, Protein APC

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:500 - 1:2000; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using FNab00473 (APC Antibody) at dilution of 1:100

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab00473(APC antibody) at dilution of 1:1000

Gene ID: 324

Research Area: Metabolism

Uniprot ID: P25054