anti- ARHGEF18 antibody

Product Description

anti- ARHGEF18 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Acts as guanine nucleotide exchange factor(GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species(ROS). Does not act as a GEF for CDC42. The G protein beta-gamma(Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells(PubMed:22006950)..

Immunogen: rho/rac guanine nucleotide exchange factor(GEF) 18

Synonyms: KIAA0521

Reactivity: Human, Mouse

Tested Application: ELISA, WB, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human pancreas cancer using FNab00561(ARHGEF18 antibody) at dilution of 1:50

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Image 4: mouse testis tissue were subjected to SDS PAGE followed by western blot with FNab00561(ARHGEF18 antibody) at dilution of 1:300

Gene ID: 23370

Research Area: Metabolism

Uniprot ID: Q6ZSZ5