anti- ARHGEF5 antibody

Product Description

anti- ARHGEF5 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Guanine nucleotide exchange factor which activates Rho GTPases(PubMed:15601624). Strongly activates RHOA(PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1(By similarity). Involved in regulation of cell shape and actin cytoskeletal organization(PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia(PubMed:14662653). Required for SRC-induced podosome formation(By similarity). Involved in positive regulation of immature dendritic cell migration(By similarity)..

Immunogen: Rho guanine nucleotide exchange factor(GEF) 5

Synonyms: TIM

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab00563(ARHGEF5 Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

Image 2: .

Image 3:

Image 4: MCF7 cells were subjected to SDS PAGE followed by western blot with FNab00563(ARHGEF5 antibody) at dilution of 1:500

Gene ID: 7984

Research Area: Metabolism

Uniprot ID: Q12774