anti- ATF6 antibody

Product Description

anti- ATF6 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response(UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element(ERSE)(5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II(5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina..

Immunogen: activating transcription factor 6

Synonyms: ATF6, ATF6 alpha, ATF6A

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IF, IHC, IP

Recommended dilution: WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

Image 1: Immunohistochemistry of paraffin-embedded human cervical cancer tissue slide using FNab00664(ATF6 Antibody) at dilution of 1:50

Image 2: Immunofluorescent analysis of HeLa cells using FNab00664 (ATF6 antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG.

Image 3:

Image 4: MCF-7 cells were subjected to SDS PAGE followed by western blot with FNab00664(ATF6 Antibody) at dilution of 1:3000

Gene ID: 22926

Research Area: Metabolism

Uniprot ID: P18850