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Product Description
anti- ATG4D antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport(Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine(PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability..
Immunogen: ATG4 autophagy related 4 homolog D(S. cerevisiae)
Synonyms: APG4 D, APG4D, ATG4D, AUTL4, Autophagin 4, Cysteine protease ATG4D
Reactivity: Human, Mouse, Rat
Tested Application: ELISA, WB
Recommended dilution: WB: 1:500-1:1000
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Image 4: mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab00676(ATG4D antibody) at dilution of 1:500
Gene ID: 84971
Research Area: Metabolism
Uniprot ID: Q86TL0
