anti- AXIN1 antibody

Product Description

anti- AXIN1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development..

Immunogen: axin 1

Synonyms: AXIN, axin 1, AXIN1, Axis inhibition protein 1, hAxin

Reactivity: Human

Tested Application: ELISA, WB

Recommended dilution: WB: 1:500-1:2000

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Image 4: A431 cells were subjected to SDS PAGE followed by western blot with FNab00752( AXIN1 Antibody) at dilution of 1:600

Gene ID: 8312

Research Area: Metabolism

Uniprot ID: O15169