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Product Description
anti- AXL antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors(TLRs)-mediated innate immune response. (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope(PubMed:22156524, PubMed:22673088, PubMed:25277499, PubMed:21501828). Acts as a receptor for ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope(PubMed:17005688)..
Immunogen: AXL receptor tyrosine kinase
Synonyms: AXL, AXL oncogene, AXL receptor tyrosine kinase, JTK11, UFO
Reactivity: Human, Mouse, Rat
Tested Application: ELISA, WB, IP, FC
Recommended dilution: WB: 1:500-1:3000; IP: 1:500-1:2000
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Image 4: HepG2 cells were subjected to SDS PAGE followed by western blot with FNab00754(AXL antibody) at dilution of 1:500
Gene ID: 558
Research Area: Metabolism
Uniprot ID: P30530
