anti- BBS7 antibody

Product Description

anti- BBS7 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor(GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog(SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization..

Immunogen: Bardet-Biedl syndrome 7

Synonyms: BBS2L1

Reactivity: Human, Mouse

Tested Application: ELISA, WB, IHC, IP

Recommended dilution: WB: 1:500-1:3000; IP: 1:500-1:1000; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human testis using FNab00823(BBS7 antibody) at dilution of 1:50

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Image 4: human brain tissue were subjected to SDS PAGE followed by western blot with FNab00823(BBS7 antibody) at dilution of 1:1500

Gene ID: 55212

Research Area: Metabolism

Uniprot ID: Q8IWZ6