anti- BCL2L1 antibody

Product Description

anti- BCL2L1 antibody is available at Gentaur for Next week Delivery.

Purification: Protein A+G purification

Background: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel(VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release(PubMed:17418785). Isoform Bcl-X(S) promotes apoptosis..

Immunogen: BCL2-like 1

Synonyms: BCL2L, BCLX

Reactivity: Human

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:2000-1:20000; IHC: 1:200-1:600; IF: 1:10-1:100

Image 1: Immunohistochemistry of paraffin-embedded human testis using FNab00843(Bcl-xL antibody) at dilution of 1:50

Image 2: Immunofluorescent analysis of Hela cells, using BCL2L1 antibody FNab00843 at 1:25 dilution and Rhodamine-labeled goat anti-mouse IgG (red)..

Image 3:

Image 4: Raw 264.7 cells were subjected to SDS PAGE followed by western blot with FNab00843(Bcl-xL Antibody) at dilution of 1:20000

Gene ID: 598

Research Area: Metabolism

Uniprot ID: Q07817