anti- beta-Catenin antibody

Product Description

anti- beta-Catenin antibody is available at Gentaur for Next week Delivery.

Purification: protein A+G purified

Background: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants..

Immunogen: catenin(cadherin-associated protein), beta 1, 88kDa

Synonyms: b cat, Beta catenin, beta-Catenin, Catenin beta 1, CTNNB, CTNNB1, PRO2286, ? catenin, ?-catenin

Reactivity: Human, Mouse, Rat, Pig

Tested Application: ELISA, IF, WB, IHC, IP

Recommended dilution: WB: 1:2000-1:20000; IP: 1:1000-1:5000; IHC: 1:200-1:1000; IF: 1:20-1:500

Image 1: Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using FNab09781(B-catenin Antibody) at dilution of 1:200

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Image 4: A431 cells were subjected to SDS PAGE followed by western blot with FNab09781(B-catenin antibody) at dilution of 1:5000

Gene ID: 1499

Research Area: Metabolism

Uniprot ID: P35222