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Product Description
anti- BHLHE22 antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Inhibits DNA binding of TCF3/E47 homodimers and TCF3(E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA(By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal chord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation..
Immunogen: basic helix-loop-helix family, member e22
Synonyms: BHLHB5, TNRC20
Reactivity: Human, Mouse
Tested Application: ELISA, WB, IF
Recommended dilution: WB: 1:200-1:1000; IF: 1:10-1:100
Image 1:
Image 2: Immunofluorescent analysis of SH-SY5Y cells using FNab00887 (BHLHE22 antibody) at dilution of 1:25 and Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L).
Image 3:
Image 4: SH-SY5Y cells were subjected to SDS PAGE followed by western blot with FNab00887(BHLHE22 Antibody) at dilution of 1:300
Gene ID: 27319
Research Area: Metabolism
Uniprot ID: Q8NFJ8
