anti- BLNK antibody

Product Description

anti- BLNK antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Functions as a central linker protein, downstream of the B-cell receptor(BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3(PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis..

Immunogen: B-cell linker

Synonyms: BASH, SLP65

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using FNab00908(BLNK Antibody) at dilution of 1:400 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

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Image 4: Raji cells were subjected to SDS PAGE followed by western blot with FNab00908(BLNK Antibody) at dilution of 1:1000

Gene ID: 29760

Research Area: Metabolism

Uniprot ID: Q8WV28