anti- c-Met antibody

Product Description

anti- c-Met antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: c-Met(also named as MET or HGFR) is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. c-Met regulates many physiological processes including proliferation, scattering, morphogenesis and survival. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Overexpression and/or mutation of c-Met has been reported in various human malignancies, including lung cancer, breast cancer, head and neck cancer, gastric cancer, colorectal cancer, bladder cancer, uterine cervix carcinoma, and esophageal carcinoma, c-Met could serve as an important therapeutic target(PMID: 26036285). This antibody recognizes the N-term of c-Met..

Immunogen: met proto-oncogene(hepatocyte growth factor receptor)

Synonyms: AUTS9, c-Met, HGF receptor, HGF/SF receptor, HGFR, MET, Proto oncogene c Met, RCCP2, Scatter factor receptor, SF receptor, Tyrosine protein kinase Met

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:500-1:1000; IHC: 1:50-1:200

Image 1: Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab01786(MET Antibody) at dilution of 1:50

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab01786(MET antibody) at dilution of 1:500

Gene ID: 4233

Research Area: Metabolism

Uniprot ID: P08581