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Product Description
anti- CALCOCO2 antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting galectin-8-associated bacteria for autophagy(PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation(PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C(PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion(PubMed:17635994)..
Immunogen: calcium binding and coiled-coil domain 2
Synonyms: NDP52
Reactivity: Human, Mouse, Rat
Tested Application: ELISA, WB, IHC, IP
Recommended dilution:
Image 1: Immunohistochemistry of paraffin-embedded human ovary tumor using FNab01196(CALCOCO2 antibody) at dilution of 1:100
Image 2: .
Image 3:
Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab01196(CALCOCO2 antibody) at dilution of 1:1000
Gene ID: 10241
Research Area: Metabolism
Uniprot ID: Q13137
