anti- CBFA2T3 antibody

Product Description

anti- CBFA2T3 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes(PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner(PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway(PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A(PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes(By similarity). Plays a role in granulocyte differentiation(PubMed:15231665). Isoform 2 functions as an A-kinase-anchoring protein(PubMed:11823486)..

Immunogen: core-binding factor, runt domain, alpha subunit 2; translocated to, 3

Synonyms: MTG16, MTGR2, ZMYND4

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB

Recommended dilution:

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Image 4: Jurkat cells were subjected to SDS PAGE followed by western blot with FNab01316(CBFA2T3 antibody) at dilution of 1:1000

Gene ID: 863

Research Area: Metabolism

Uniprot ID: O75081