anti- CBLC antibody

Product Description

anti- CBLC antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival..

Immunogen: Cas-Br-M(murine) ecotropic retroviral transforming sequence c

Synonyms: CBL3, RNF57

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB

Recommended dilution:

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Image 4: mouse lung tissue were subjected to SDS PAGE followed by western blot with FNab01319(CBLC antibody) at dilution of 1:500

Gene ID: 23624

Research Area: Metabolism

Uniprot ID: Q9ULV8