anti- CCDC22 antibody

Product Description

anti- CCDC22 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via assocation with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10(PubMed:23563313). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes(PubMed:25355947)..

Immunogen: coiled-coil domain containing 22

Synonyms: CXorf37

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB

Recommended dilution:

Image 1:

Image 2: .

Image 3:

Image 4: human brain tissue were subjected to SDS PAGE followed by western blot with FNab01350(CCDC22 antibody) at dilution of 1:500

Gene ID: 28952

Research Area: Metabolism

Uniprot ID: O60826