anti- CENPF antibody

Product Description

anti- CENPF antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia..

Immunogen: centromere protein F, 350/400ka(mitosin)

Synonyms:

Reactivity: Human

Tested Application: ELISA, IHC, IF

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human heart tissue slide using FNab01585(CENPF Antibody) at dilution of 1:200

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Gene ID: 1063

Research Area: Metabolism

Uniprot ID: P49454