anti- CEP152 antibody

Product Description

anti- CEP152 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication(PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation(PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure(PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles(By similarity). Overexpression of CEP152 can drive amplification of centrioles(PubMed:20852615)..

Immunogen: centrosomal protein 152kDa

Synonyms: KIAA0912

Reactivity: Human, Mouse

Tested Application: ELISA, IP, WB

Recommended dilution:

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Image 4: mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab01597( CEP152 Antibody) at dilution of 1:300

Gene ID: 22995

Research Area: Metabolism

Uniprot ID: O94986