anti- CHCHD4 antibody

Product Description

anti- CHCHD4 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1(PubMed:16185709, PubMed:26387864, PubMed:19182799, PubMed:21059946, PubMed:23186364). Required for the import and folding of small cysteine-containing proteins(small Tim) in the mitochondrial intermembrane space(IMS)(PubMed:16185709, PubMed:19182799, PubMed:21059946). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria(PubMed:16185709, PubMed:19182799, PubMed:21059946). The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS(PubMed:16185709, PubMed:19182799, PubMed:21059946). Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system(PubMed:23186364). Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake(PubMed:26387864)..

Immunogen: coiled-coil-helix-coiled-coil-helix domain containing 4

Synonyms: MIA40

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, IHC, IF, WB, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human kidney using FNab01637(CHCHD4 antibody) at dilution of 1:100

Image 2: .

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Image 4: rat brain tissue were subjected to SDS PAGE followed by western blot with FNab01637(CHCHD4 Antibody) at dilution of 1:1500

Gene ID: 131474

Research Area: Metabolism

Uniprot ID: Q8N4Q1