anti- CHFR antibody

Product Description

anti- CHFR antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2(UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress..

Immunogen: checkpoint with forkhead and ring finger domains

Synonyms: RNF196

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human endometrial cancer using FNab01648(CHFR antibody) at dilution of 1:100

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Image 4: HepG2 cells were subjected to SDS PAGE followed by western blot with FNab01648(CHFR antibody) at dilution of 1:1000

Gene ID: 55743

Research Area: Metabolism

Uniprot ID: Q96EP1