anti- Chk2 antibody

Product Description

anti- Chk2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene..

Immunogen: CHK2 checkpoint homolog (S. pombe)

Synonyms:

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Image 1: Immunohistochemistry of paraffin-embedded human testis tissue slide using FNab01654(Chk2 antibody) at dilution of 1:100

Image 2: Immunofluorescence analysis of A549 cells using FNab01654(Chk2 antibody) at dilution of 1:100.

Image 3:

Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab01654(Chk2 antibody) at dilution of 1:1000

Gene ID: 11200

Research Area: Metabolism

Uniprot ID: O96017