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Product Description
anti- CLK2 antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine-and arginine-rich(SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor(F3) pre-mRNA in endothelial cells..
Immunogen: CDC-like kinase 2
Synonyms:
Reactivity: Human, Mouse, Rat
Tested Application: ELISA
Recommended dilution:
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Gene ID: 1196
Research Area: Metabolism
Uniprot ID: P49760
