anti- CLP1 antibody

Product Description

anti- CLP1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA(dsRNA), single-stranded RNA(ssRNA), double-stranded DNA(dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA(PubMed:24766809, PubMed:24766810). Its role in tRNA splicing and maturation is required for cerebellar development(PubMed:24766809, PubMed:24766810). Component of the pre-mRNA cleavage complex II(CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs(siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex(RISC). However, endogenous siRNAs and microRNAs(miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing..

Immunogen: CLP1, cleavage and polyadenylation factor I subunit, homolog(S. cerevisiae)

Synonyms: HEAB

Reactivity: Human, Mouse

Tested Application: ELISA, WB

Recommended dilution:

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Image 4: mouse testis tissue were subjected to SDS PAGE followed by western blot with FNab01770(CLP1 antibody) at dilution of 1:600

Gene ID: 10978

Research Area: Metabolism

Uniprot ID: Q92989