anti- CNOT1 antibody

Product Description

anti- CNOT1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element(ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem(ES) cell identity..

Immunogen: CCR4-NOT transcription complex, subunit 1

Synonyms: CDC39, KIAA1007, NOT1

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, IHC, WB, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human heart tissue slide using FNab01805(CNOT1 Antibody) at dilution of 1:200

Image 2: .

Image 3:

Image 4: human brain tissue were subjected to SDS PAGE followed by western blot with FNab01805(CNOT1 antibody) at dilution of 1:800

Gene ID: 23019

Research Area: Metabolism

Uniprot ID: A5YKK6