anti- COPS7A antibody

Product Description

anti- COPS7A antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Component of the COP9 signalosome complex(CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin(Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively..

Immunogen: COP9 constitutive photomorphogenic homolog subunit 7A(Arabidopsis)

Synonyms: CSN7A, DERP10

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human kidney using FNab01873(COPS7A antibody) at dilution of 1:50

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Image 4: human heart tissue were subjected to SDS PAGE followed by western blot with FNab01873(COPS7A antibody) at dilution of 1:300

Gene ID: 50813

Research Area: Metabolism

Uniprot ID: Q9UBW8