anti- COPS8 antibody

Product Description

anti- COPS8 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Component of the COP9 signalosome complex(CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin(Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively..

Immunogen: COP9 constitutive photomorphogenic homolog subunit 8(Arabidopsis)

Synonyms: COP9, COP9 homolog, COPS8, CSN8, hCOP9, SGN8, Signalosome subunit 8

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:200-1:2000; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded mouse brain tissue slide using FNab01874(COPS8 Antibody) at dilution of 1:50

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Image 4: mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab01874(COPS8 Antibody) at dilution of 1:600

Gene ID: 10920

Research Area: Metabolism

Uniprot ID: Q99627