anti- CRBN antibody

Product Description

anti- CRBN antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Substrate recognition component of a DCX(DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3..

Immunogen: cereblon

Synonyms: cereblon, CRBN, MRT2A, Protein cereblon

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:500-1:2000; IHC: 1:50-1:200

Image 1: Immunohistochemistry of paraffin-embedded human cervical cancer tissue slide using FNab01954(CRBN Antibody) at dilution of 1:200

Image 2: .

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Image 4: mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab01954(CRBN antibody) at dilution of 1:1000

Gene ID: 51185

Research Area: Metabolism

Uniprot ID: Q96SW2