anti- CREB3L2 antibody

Product Description

anti- CREB3L2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Transcription factor involved in unfolded protein response(UPR). In the absence of endoplasmic reticulum(ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes(By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death(PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site(PubMed:17178827)..

Immunogen: cAMP responsive element binding protein 3-like 2

Synonyms: BBF2H7

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB

Recommended dilution:

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Image 4: HepG2 cells were subjected to SDS PAGE followed by western blot with FNab01964( CREB3L2 Antibody) at dilution of 1:600

Gene ID: 64764

Research Area: Metabolism

Uniprot ID: Q70SY1