anti- CSE1L antibody

Product Description

anti- CSE1L antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates(cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex(NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP(induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus..

Immunogen: CSE1 chromosome segregation 1-like(yeast)

Synonyms: CAS, XPO2

Reactivity: Human, Mouse

Tested Application: ELISA, WB, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human breast cancer using FNab02012(CSE1L antibody) at dilution of 1:50

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab02012(CSE1L antibody) at dilution of 1:1000

Gene ID: 1434

Research Area: Metabolism

Uniprot ID: P55060