anti- CSK antibody

Product Description

anti- CSK antibody is available at Gentaur for Next week Delivery.

Purification: Protein A+G purification

Background: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases(SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor(TCR) and B-cell receptor(BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK..

Immunogen: c-src tyrosine kinase

Synonyms: C Src kinase, c src tyrosine kinase, CSK, Protein tyrosine kinase CYL, Tyrosine protein kinase CSK

Reactivity: Human, Mouse

Tested Application: ELISA, WB, IF

Recommended dilution: WB: 1:500-1:2000; IF: 1:20-1:200

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Image 4: Jurkat cells were subjected to SDS PAGE followed by western blot with FNab02017(CSK antibody) at dilution of 1:1000

Gene ID: 1445

Research Area: Metabolism

Uniprot ID: P41240