anti- CTNNA1 antibody

Product Description

anti- CTNNA1 antibody is available at Gentaur for Next week Delivery.

Purification: Protein A+G purification

Background: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E-and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation..

Immunogen: catenin(cadherin-associated protein), alpha 1, 102kDa

Synonyms: Alpha E catenin, Cadherin associated protein, CAP102, Catenin alpha 1, CTNNA1

Reactivity: Human, Mouse

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:500-1:2000; IHC: 1:50-1:1000

Image 1: Immunohistochemistry of paraffin-embedded human stomach tissue slide using FNab02056(CTNNA1 Antibody) at dilution of 1:200

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Image 4: NIH/3T3 cells were subjected to SDS PAGE followed by western blot with FNab02056(CTNNA1 Antibody) at dilution of 1:1000

Gene ID: 1495

Research Area: Metabolism

Uniprot ID: P35221