anti- CUL2 antibody

Product Description

anti- CUL2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Core component of multiple cullin-RING-based ECS(ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1(By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor(HIF)..

Immunogen: cullin 2

Synonyms:

Reactivity: Human

Tested Application: ELISA, WB, IHC, IF, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human prostate cancer using FNab02074(CUL2 antibody) at dilution of 1:50

Image 2: .

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab02074(CUL2 antibody) at dilution of 1:100

Gene ID: 8453

Research Area: Metabolism

Uniprot ID: Q13617