anti- CUL4A antibody

Product Description

anti- CUL4A antibody is available at Gentaur for Next week Delivery.

Purification: Protein A+G purification

Background: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled(H3.1) and replication-independent(H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL..

Immunogen: cullin 4A

Synonyms:

Reactivity: Human, Monkey, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP, IF

Recommended dilution: WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human heart tissue slide using FNab02077(CUL4A Antibody) at dilution of 1:200

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab02077(CUL4A antibody) at dilution of 1:500

Gene ID: 8451

Research Area: Metabolism

Uniprot ID: Q13619