anti- CYLD antibody

Product Description

anti- CYLD antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation(PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation(PubMed:12917690). Negative regulator of Wnt signaling(PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules(PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis(PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis(PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation(PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis(By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation(By similarity)..

Immunogen: cylindromatosis(turban tumor syndrome)

Synonyms: CYLD1, KIAA0849

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recommended dilution: WB: 1:500-1:1000; IP: 1:200-1:1000; IHC: 1:50-1:500

Image 1: Immunohistochemistry of paraffin-embedded human colon cancer using FNab02142(CYLD antibody) at dilution of 1:50

Image 2: .

Image 3: IP Result of anti-CYLD (IP: FNab02142, 4ug; Detection: FNab02142 1:300) with mouse brain tissue lysate 4000ug.

Image 4: A431 cells were subjected to SDS PAGE followed by western blot with FNab02142(CYLD antibody) at dilution of 1:500

Gene ID:

Research Area: Metabolism

Uniprot ID: Q9NQC7