anti- CYP1B1 antibody

Product Description

anti- CYP1B1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta-estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or activity, during angiogenesis. Contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression..

Immunogen: cytochrome P450, family 1, subfamily B, polypeptide 1

Synonyms:

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using FNab02149(CYP1B1 Antibody) at dilution of 1:50

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Image 4: MCF-7 cells were subjected to SDS PAGE followed by western blot with FNab02149(CYP1B1 Antibody) at dilution of 1:600

Gene ID: 1545

Research Area: Metabolism

Uniprot ID: Q16678