anti- CYP26B1 antibody

Product Description

anti- CYP26B1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Involved in the metabolism of retinoic acid(RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid(all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo..

Immunogen: cytochrome P450, family 26, subfamily B, polypeptide 1

Synonyms: CYP26A2, P450RAI2

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human hepatocirrhosis using FNab02152(CYP26B1 antibody) at dilution of 1:50

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Image 4: human brain tissue were subjected to SDS PAGE followed by western blot with FNab02152(CYP26B1 antibody) at dilution of 1:500

Gene ID: 56603

Research Area: Metabolism

Uniprot ID: Q9NR63